KLK2 is a serine protease produced by secretory epithelial cells in the prostate (1). It is a glandular kallikrein that cleaves Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin (2). KLK2 can activate the proforms of PSA (prostate-specific antigen) and urokinase type plasminogen activator and inactivate plasminogen activator inhibitor-1, suggesting a possible role in a proteolytic cascade associated with prostate cancer. Thus, it may promote tumor growth, and metastasis and inhibition of KLK2 activity may, therefore, slow down tumor spread (1).
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