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Anti-JNK3 Antibody EPR5493(2)
Also for JNK3 (NM_002753)
|A synthetic peptide corresponding to residues near the C-terminus of human JNK3 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IF
||WB: 1:1000 - 1:10000; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for IHC-P or IP.
|Homo sapiens mitogen-activated protein kinase 10 (MAPK10), transcript variant 1|
|JNK3; JNK3A; p493F12; p54bSAPK; PRKM10; SAPK1b|
Entrez Gene 5602 Human
Entrez Gene 26414 Mouse
Entrez Gene 25272 Rat
|JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and they are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis (1). |
|Protein KinaseDruggable Genome MAPK signaling pathwayErbB signaling pathwayWnt signaling pathwayFocal adhesionToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >> |
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Western blot - Anti-MAPK10 antibody [EPR5493(2)]; All lanes : Anti-MAPK10 antibody [EPR5493(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : 293T cell lysate.Lane 3 : SH-SY5Y cell lysate.Lane 4 : Human heart lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 53 kDa.
Other-Anti-MAPK10 antibody [EPR5493(2)](TA310639); Equilibrium disassociation constant (KD)..
Immunocytochemistry/ Immunofluorescence - Anti-MAPK10 antibody [EPR5493(2)]; TA310639 at 1/100 dilution staining MAPK10 in 293 cells by immunofluorescence.