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Anti-JNK2 Antibody EP1595Y

WB(1)

IHC(1)

Gene Name Homo sapiens mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-g Synonyms: JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; p54a; p54aSAPK; PRKM9; SAPK; SAPK1a Immunogen A synthetic peptide corresponding to residues near the C-terminus of human JNK2 was used as an immunogen. Buffer Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt. Clone Name EP1595Y Isotype Species Reactivity Human, Mouse, Rat Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB, IHC Suggested Dilutions WB: 1:1000 - 10,000; Background JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3). Related Pathway Focal Adhesion MAPK signaling pathway TGF Beta Signaling Pathway Toll-like receptor signaling pathway Wnt Signaling Pathway

Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • MAPK9 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • MAPK9 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Mapk9 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • MAPK9 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Mapk9 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-g as transfection-ready DNA • GFP-tagged ORF clone of Homo sapiens mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-g as transfection-ready DNA Related cDNA Clones • Homo sapiens mitogen-activated protein kinase 9 (MAPK9), transcript variant JNK2-g as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)