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Home Antibody All anti-JAK1 antibodies

Anti-JAK1 Antibody EPR349(N)

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SKU Description Amount Price Availability*  
TA310636 Rabbit Monoclonal antibody against JAK1 100ul $325 In Stock
LC400824 JAK1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human JAK1 was used as an immunogen.
Clone NameEPR349(N) IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
Predicted MW Explanation 133 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens Janus kinase 1 (JAK1)
Alternative NameJAK1A; JAK1B; JTK3
Database LinkNP_002218
Entrez Gene 3716 Human
Entrez Gene 16451 Mouse
Entrez Gene 84598 Rat
FunctionJanus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs (1).
Related PathwayProtein KinaseDruggable Genome Jak-STAT signaling pathwayPathways in cancerPancreatic cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-JAK1 antibody [EPR349(N)]; All lanes : Anti-JAK1 antibody [EPR349(N)] at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : HT-29 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 133 kDa.
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