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Anti-ITPR1 Antibody EPR4536
Also for ITPR1 (NM_001099952)
|A synthetic peptide corresponding to residues in human ITPR1 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05% (Protein A or G Sepharose)
|Is unsuitable for IP.
|Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant 1|
|INSP3R1; IP3R; IP3R1; SCA15; SCA16; SCA29|
|ITPR1 is an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.|
Signaling by GPCR
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Western blot - Anti-ITPR1 antibody [EPR4536]; All lanes : Anti-IP3 receptor antibody [EPR4536] at 1/1000 dilution.Lane 1 : SH-SY5Y cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : HuT78 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 314 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR1 antibody [EPR4536]; ab125076, at 1/50, staining ITPR1 in paraffin-embedded Human brain tissue by immunohistochemistry.