Anti-ITPR1 Antibody, EPR4536

Also for ITPR1 (NM_001099952)

Gene Name	Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant 1
Synonyms:	INSP3R1; IP3R; IP3R1; SCA15; SCA16; SCA29
Immunogen	A synthetic peptide corresponding to residues in human ITPR1 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR4536	Isotype
Species Reactivity	Human	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000; IHC 1:100 - 250; IP: 1:10 - 100;
Background	ITPR1 is an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.
Related Pathway	Hemostasis Signaling by GPCR

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WB Image

Western blot analysis on (A) SH-SY5Y, (B) HeLa, and (C) HuT-78 cell lysates using anti-ITPR1 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-ITPR1 RabMAb.

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Anti-ITPR1 Antibody EPR4536

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