OriGene Technologies, Inc.
Left ProductsProducts divider ServicesServices divider technologyTechnology divider researchResearch divider TechsupportTechSupport divider AboutAbout Right
 
Home Antibody All anti-ITCH antibodies

Anti-ITCH Antibody EPR4937

div

Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310633
  • Rabbit Monoclonal antibody against ITCH
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403120) , 20ug
100ul 325 3-7 Days
Add to Shopping Cart
WB(1)
IHC(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human ITCH was used as an immunogen.
Clone NameEPR4937 IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:500 - 1:1000
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 1
Alternative NameAIF4; AIP4; dJ468O1.1; NAPP1
Database LinkNP_001244066
FunctionITCH, or Atrophin-1, contains a polyglutamine repeat, the expansion of which is responsible for dentatorubral and pallidoluysian atrophy. It is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. ITCH contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2, and it may participate in the regulation of immune responses by modifying Notch-mediated signaling. ITCH is highly similar to the mouse ITCH protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Related Pathway
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway

* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - ITCH/AIP4 antibody [epr4937]; All lanes : Anti-ITCH/AIP4 antibody [EPR4937] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : HL60 cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : MCF7 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 103 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - ITCH/AIP4 antibody [epr4937]; Immunohistochemical analysis of ITCH/AIP4 expression in paraffin-embedded Human breast tissue using TA310633 at 1/500 dilution.

 

spacer
Inc 5000 Healthcare Company Copyright © 2014 OriGene Technologies, Inc. All Rights Reserved. Legal Notices.
9620 Medical Center Dr., Suite 200, Rockville, MD 20850 • 1.888.267.4436

Reproduction of any materials from this website is strictly forbidden without permission.

All Products by: Title | Price | Category | Popularity | Best Sellers Topselling Products by: Title | Price | Category | Popularity | Favorites
Popular Categories: Popularity | Our Choices | All-Round Favorites | Title Topselling Categories: Popularity | Our Choices | All-Round Favorites | Title