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Anti-ITCH Antibody epr4937
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Also for ITCH (NM_001257137)
|A synthetic peptide corresponding to residues in human ITCH was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:1,000 - 10,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 1|
|AIF4; AIP4; dJ468O1.1; NAPP1|
|ITCH, or Atrophin-1, contains a polyglutamine repeat, the expansion of which is responsible for dentatorubral and pallidoluysian atrophy. It is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. ITCH contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2, and it may participate in the regulation of immune responses by modifying Notch-mediated signaling. ITCH is highly similar to the mouse ITCH protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.|
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
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Western blot analysis on (A) K562, (B) HL-60, (C) HeLa, and (D) MCF-7 cell lysates using anti-ITCH RabMAb.
Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-ITCH RabMAb.