Anti-ITCH Antibody, epr4937

Also for ITCH (NM_001257137)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues in human ITCH was used as an immunogen.
Clone Name	epr4937	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:1,000 - 10,000;
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens itchy E3 ubiquitin protein ligase (ITCH), transcript variant 1
Alternative Name	AIF4; AIP4; dJ468O1.1; NAPP1
Database Link	NP_001244066
Function	ITCH, or Atrophin-1, contains a polyglutamine repeat, the expansion of which is responsible for dentatorubral and pallidoluysian atrophy. It is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. ITCH contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2, and it may participate in the regulation of immune responses by modifying Notch-mediated signaling. ITCH is highly similar to the mouse ITCH protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.
Related Pathway	Delta-Notch Signaling Pathway EGFR1 Signaling Pathway

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WB Image

Western blot analysis on (A) K562, (B) HL-60, (C) HeLa, and (D) MCF-7 cell lysates using anti-ITCH RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-ITCH RabMAb.

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

HRP
Biotin
PE
FITC
DyLight® 488
DyLight® 550
DyLight® 594
DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Anti-ITCH Antibody epr4937

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data