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Anti-IL1B Antibody EP408Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against IL-1 beta (C-term) (IL1B)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400196) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-terminus of human IL1-beta was used as immunogen
Clone NameEP408Y IsotypeIgG
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens interleukin 1, beta (IL1B)
Alternative NameIL-1; IL1-BETA; IL1F2
Database LinkNP_000567
Entrez Gene 3553 Human
FunctionInterleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family. There are two known forms of IL1, IL1 alpha (predominant form in mice) and IL1 beta (predominant form in humans). IL1 beta and alpha are both synthesized as precursor. The IL1 beta precursor form is not biologically active, while IL1 alpha is. Expressed mainly by stimulated macrophages and monocytes, IL1 beta precursor is cleaved by Caspase 1/ICE and other proteases (2-3). Activated IL1 alpha remains mostly in the cytosol, activated IL1 beta is widely secreted. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohn's disease which makes IL1 beta an important target for this disease (4).
Related PathwaySecreted ProteinDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayCytosolic DNA-sensing pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Anti-IL1 beta antibody [EP408Y] (TA310621) at 1/5000 dilution + approximately 0.05ug of recombinant IL1 beta


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