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Anti-IL12A Antibody EP5737
Also for IL12A (NM_000882)
|A synthetic peptide corresponding to residues near the C-terminus of human IL-12 alpha was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; FC: 1:100 - 1:500
|Does not react with Rat. Is unsuitable for ICC or IP.|
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for ICC or IP.
|Homo sapiens interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)|
|CLMF; IL-12A; NFSK; NKSF1; P35|
|IL-12 alpha is a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit protein (IL-12 alpha), and a 40-kD subunit (IL-12 beta) that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity (1). |
Cytokine-cytokine receptor interaction
Jak-STAT signaling pathway
Toll-like receptor signaling pathway
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Western blot - Anti-IL12A antibody [EP5737]; All lanes : Anti-IL12A antibody [EP5737] at 1/1000 dilution.Lane 1 : NIH3T3 cell lysate.Lane 2 : HuT-78 cell lysate.Lane 3 : Raw 264.7 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 25 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IL12A antibody [EP5737]; Immunohistochemical analysis of paraffin-embedded Human kidney tissue labelling IL12A with ab131039 antibody at 1/250 dilution.