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Anti-IKBKE Antibody EPR4904

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA310614
  • Rabbit Monoclonal antibody against IKK epsilon (IKBKE)
100ul $325 3-7 Days
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WB(1)
IHC(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human IKK epsilon was used as an immunogen.
Clone NameEPR4904 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250; FC: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE), transcript variant 3
Alternative NameIKK-E; IKK-i; IKKE; IKKI
Database LinkNP_001180250
Entrez Gene 9641 Human
FunctionIKK epsilon is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. It has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (1). IKK epsilon phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. It plays a special role in the immune response. IKK epsilon protects cells against DNA damage-induced cell death (2).
Related PathwayProtein KinaseDruggable Genome Toll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayCytosolic DNA-sensing pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-IKKi/IKKe antibody [EPR4904]; All lanes : Anti-IKKi/IKKe antibody [EPR4904] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : Raji cell lysate.Lane 3 : MCF7 cell lysate.Lane 4 : Jurkat cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 80 kDa.
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Other-Anti-IKKi/IKKe antibody [EPR4904](TA310614); Equilibrium disassociation constant (KD)..
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IKKi/IKKe antibody [EPR4904]; TA310614, at 1/100 dilution, staining IKKi/IKKe in paraffin-embedded Human tonsil tissue by Immunohistochemistry.
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