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Home Antibody All anti-IFIH1 antibodies

Anti-IFIH1 Antibody EPR6743

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310607
  • Rabbit Monoclonal antibody against MDA-5 (IFIH1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC411723) , 20ug Explanation
100ul 325 In Stock
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WB(1)
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Also for IFIH1 (NM_022168)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human MDA-5 was used as an immunogen.
Clone NameEPR6743 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:250 - 1:500
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens interferon induced with helicase C domain 1 (IFIH1)
Alternative NameAGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2
Database LinkNP_071451
Entrez Gene 64135 Human
FunctionDEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. MDA-5 is a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation (1).
Related Pathway RIG-I-like receptor signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-MDA5 antibody [EPR6743]; Anti-MDA5 antibody [EPR6743] at 1/1000 dilution + THP1 treated with LPS cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 117 kDa.

 

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