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Anti-IFIH1 Antibody EPR6743
Also for IFIH1 (NM_022168)
|A synthetic peptide corresponding to residues in human MDA-5 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; ICC/IF: 1:250 - 1:500
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,IHC-P or IP.
|Homo sapiens interferon induced with helicase C domain 1 (IFIH1)|
|AGS7; Hlcd; IDDM19; MDA-5; MDA5; RLR-2|
Entrez Gene 64135 Human
|DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. MDA-5 is a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation (1).|
| RIG-I-like receptor signaling pathway|
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Western blot - Anti-MDA5 antibody [EPR6743]; Anti-MDA5 antibody [EPR6743] at 1/1000 dilution + THP1 treated with LPS cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 117 kDa.