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Home Antibody All anti-IDE antibodies

Anti-IDE Antibody EPR6099

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310606
  • Rabbit Monoclonal antibody against IDE
100ul 325 In Stock
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WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human IDE was used as an immunogen.
Clone NameEPR6099 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:10000 - 1:50000; ICC: 1:50 - 1:100
Predicted MW Explanation 118 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens insulin-degrading enzyme (IDE), transcript variant 2
Alternative NameINSULYSIN
Database LinkNP_001159418
Entrez Gene 3416 Human
Entrez Gene 15925 Mouse
Entrez Gene 25700 Rat
FunctionIDE is a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in IDE's function are associated with Alzheimer's disease and type 2 diabetes mellitus, but mutations in IDE have not been shown to be causative for these diseases. It localizes primarily in the cytoplasm, but in some cell types it localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion (1).
Related PathwayProteaseDruggable Genome Alzheimer's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Insulin degrading enzyme / IDE antibody [EPR6099]; All lanes : Anti-Insulin degrading enzyme / IDE antibody [EPR6099] at 1/10000 dilution.Lane 1 : HeLa cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : A375 cell lysate.Lane 4 : K562 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 118 kDa.

 

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