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Home Antibody All anti-ICOSLG antibodies

Anti-ICOSLG Antibody EPR6071

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310604
  • Rabbit Monoclonal antibody against B7-H2 (ICOSLG)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402420) , 20ug
100ul 325 3-7 Days
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WB(1)
Assay(1)
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Also for ICOSLG (NM_015259)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the intracellular domain of human B7-H2 was used as an immunogen.
Clone NameEPR6071 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,IHC-P or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens inducible T-cell co-stimulator ligand (ICOSLG), transcript variant 1
Alternative NameB7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS
Database LinkNP_056074
FunctionB7-H2, or Inducible costimulator ligand (ICOSL), is a member of the Ig superfamily and belongs to the B7 family of costimulatory molecules. It specifically binds to ICOS, but not to other T cell costimulatory molecules such as CD28 and CTLA-4. B7-H2-ICOS interaction appears to be very important in the expansion of activated T cells and late-phase immune responses (1). B7-H2 enhances the proliferation of both CD4 and CD8 T cells, the secretion of Th1- and/or Th2-type cytokines, and the expression of CD154 (CD40 ligand) on T cells (2). It is expressed constitutively on B lymphocytes and at low levels on monocytes (3). Furthermore, B7-H2-ICOS interaction induces IL-10 production, which plays an important role in reducing immune responses (4).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-ICOS Ligand antibody [EPR6071]; All lanes : Anti-ICOS Ligand antibody [EPR6071] at 1/1000 dilution.Lane 1 : HL60 cell lysate.Lane 2 : HuT78 cell lysate.Lane 3 : HUVEC cell lysate, treated with TNF-alpha.Lane 4 : HUVEC cell lysate .Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 33 kDa.
Assay Image
Other-Anti-ICOS Ligand antibody [EPR6071](TA310604); Equilibrium disassociation constant (KD)..

 

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