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Anti-ICOS Antibody EPR7114


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SKU Description Amount Price Availability*  
TA310603 Rabbit Monoclonal antibody against ICOS 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human ICOS was used as an immunogen.
Clone NameEPR7114 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250; FC: 1:100 - 1:500
Predicted MW Explanation 22 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens inducible T-cell co-stimulator (ICOS)
Alternative NameAILIM; CD278; CVID1
Database LinkNP_036224
Entrez Gene 29851 Human
Entrez Gene 54167 Mouse
Entrez Gene 64545 Rat
FunctionICOS belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation (1). ICOS enhances all basic T-cell responses to a foreign antigen, namely secretion of lymphokines and effective help for antibody secretion by B-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Moreover, ICOS plays a critical role in CD40-mediated class switching of immunoglobin isotypes (2).
Related PathwaySecreted ProteinTransmembrane Cell adhesion molecules (CAMs)T cell receptor signaling pathwayPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-ICOS antibody [EPR7114]; All lanes : Anti-ICOS antibody [EPR7114] at 1/1000 dilution.Lane 1 : Human tonsil lysate.Lane 2 : Jurkat cell lysate.Lane 3 : Mouse thymus lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 22 kDa.
Flow Cytometry - Anti-ICOS antibody [EPR7114]; Flow Cytometry analysis of HuT-78 cells labelling ICOS with TA310603 at 1/100 dilution (red). Rabbit IgG (negative) is shown in green.


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