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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-HTR2C antibodies

Anti-HTR2C Antibody EPR6486

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA310599
  • Rabbit Monoclonal antibody against HTR2C
  • FREE positive control: HEK293T cell transient overexpression lysate (LC424472) , 20ug
 100ul $325 3-7 Days Add to Shopping Cart
WB(1)
Gene NameHomo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C), transcript variant 2
Synonyms:5-HT2C; 5-HTR2C; HTR1C
ImmunogenA synthetic peptide corresponding to residues in human HTR2C was used as an immunogen.
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone NameEPR6486 Isotype
Species ReactivityHuman Concentration
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000; FC: 1:10 - 100;
BackgroundSerotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. HTR2C is the 2C subtype of serotonin receptor. Its isoforms differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in HTR2C in depressed suicide victims (1).
Related Pathway
Signaling by GPCR

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WB Image
Western blot analysis on (A) SH-SY5Y, (B) A431, and (C) BxPC-3 cell lysates using anti-HTR2C RabMAb.

 

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