Anti-HMGB2 Antibody, EPR6301

Also for HMGB2 (NM_001130688)

Gene Name	Homo sapiens high mobility group box 2 (HMGB2), transcript variant 2
Synonyms:	HMG2
Immunogen	A synthetic peptide corresponding to residues on the N-terminus in human HMGB2 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR6301	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB: 1:10,000 - 50,000; FC: 1:10 - 100;
Background	HMGB2 is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. HMGB2 was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination (1).
Related Pathway

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WB Image

Western blot analysis on (A) K562, (B) HeLa, and (C) PC-12 cell lysates using anti-HMGB2 RabMAb.

IHC Image

Immunohistochemical analysis of paraffin-embedded human breast tissue using anti-HMGB2 RabMAb.

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Anti-HMGB2 Antibody EPR6301

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