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Anti-GP1BA Antibody EPR6995
Also for GP1BA (NM_000173)
|A synthetic peptide corresponding to residues in the extracellular domain in human CD42b was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for ICC/IF.
|Homo sapiens glycoprotein Ib (platelet), alpha polypeptide (GP1BA)|
|BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GPIbA; VWDP|
Entrez Gene 2811 Human
|Glycoprotein Ib (GP Ib), or CD42b, is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. CD42b functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and it also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. Several mutations have been described in CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease (1).|
|TransmembraneDruggable Genome ECM-receptor interactionHematopoietic cell lineage|
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Western blot - Anti-CD42b antibody [EPR6995]; Anti-CD42b antibody [EPR6995] at 1/10000 dilution + Human platelet lysate at 10 ug.Secondary.HRP labelled Goat anti-rabbit at 1/2000 dilution.Predicted band size : 69 kDa.Observed band size : 143 kDa .
Other-Anti-CD42b antibody [EPR6995](TA310540); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD42b antibody [EPR6995]; Immunohistochemical analysis of paraffin embedded Human spleen tissue labelling CD42b with TA310540 at a dilution of 1/100.