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Home Antibody All anti-GP1BA antibodies

Anti-GP1BA Antibody EPR6995

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310540
  • Rabbit Monoclonal antibody against CD42b (GP1BA)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424885) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
Assay(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain in human CD42b was used as an immunogen.
Clone NameEPR6995 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for ICC/IF.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC/IF.

Reference Data

Target NameHomo sapiens glycoprotein Ib (platelet), alpha polypeptide (GP1BA)
Alternative NameBDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GPIbA; VWDP
Database LinkNP_000164
Entrez Gene 2811 Human
FunctionGlycoprotein Ib (GP Ib), or CD42b, is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. CD42b functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and it also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. Several mutations have been described in CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease (1).
Related PathwayTransmembraneDruggable Genome ECM-receptor interactionHematopoietic cell lineage

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-CD42b antibody [EPR6995]; Anti-CD42b antibody [EPR6995] at 1/10000 dilution + Human platelet lysate at 10 ug.Secondary.HRP labelled Goat anti-rabbit at 1/2000 dilution.Predicted band size : 69 kDa.Observed band size : 143 kDa .
Assay Image
Other-Anti-CD42b antibody [EPR6995](TA310540); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD42b antibody [EPR6995]; Immunohistochemical analysis of paraffin embedded Human spleen tissue labelling CD42b with TA310540 at a dilution of 1/100.

 

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