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Home Antibody All anti-GNB2L1 antibodies

Anti-GNB2L1 Antibody EPR7388

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310538
  • Rabbit Monoclonal antibody against RACK1 (GNB2L1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401838) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for GNB2L1 (NM_006098)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human RACK1 was used as an immunogen.
Clone NameEPR7388 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:50 - 1:100; FC: 1:10 - 1:100
Predicted MW Explanation 35 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IP.

Reference Data

Target NameHomo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1)
Alternative NameGnb2-rs1; H12.3; HLC-7; PIG21; RACK1
Database LinkNP_006089
Entrez Gene 10399 Human
Entrez Gene 14694 Mouse
Entrez Gene 83427 Rat
FunctionRACK1, a binding protein of heterotrimeric G protein ß? (Gß?) subunits, is a member of the WD40 repeat protein family that binds to activated protein kinase C (PKC) (1). It functions as an anchoring protein to stabilize PKC at the membrane in an active conformation (2). RACK1 has been shown to interact with a variety of proteins and may act as an adaptor/scaffold protein to orchestrate diverse cellular processes, ranging from signal transduction to cell growth (1). Moreover, it has a well established role in integrin and growth factor signaling. RACK1 can interact with ß1 and ß3 integrin receptors, and it regulates the assembly of protrusions necessary for cell adhesion and migration in an Src-dependent manner. RACK1 scaffolds members of the Erk signaling pathway to promote integrin-mediated activation of MAPKs (3). In addition, it is a ribosomal protein that is located at the back of the 40S head region and makes direct contact with ribosomal RNA (4).
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-RACK1 antibody [EPR7388]; All lanes : Anti-RACK1 antibody [EPR7388] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : SH-SY5Y cell lysate.Lane 3 : HeLa cell lysate.Lane 4 : PC12 cell lysate.Lane 5 : C6 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 35 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RACK1 antibody [EPR7388]; TA310538, at a dilution of 1/50, staining RACK1 in paraffin-embedded Human cervical carcinoma tissue by Immunohistochemistry.

 

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