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Anti-GCN2 Phospho Antibody EPR2320Y
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Also for GCN2 (NM_001013703)
|A phospho specific peptide corresponding to residues surrounding threonine 899 of human GCN2 was used as an immunogen. This antibody detects GCN2 phosphorylated at threonine 899.|
||WB: 1:5000 - 10,000; IP: 1:40; FC: 1:50;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4)|
|In eukaryotic cells, protein synthesis is regulated in response to various environmental stresses by phosphorylating the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha). Four different eIF2alpha kinases have been identified in mammalian cells, the heme-regulated inhibitor (HRI), the interferon-inducible RNA-dependent kinase (PKR) and the endoplasmic reticulum-resident kinase (PERK) and GCN2, which was previously characterized from Saccharomyces cerevisiae, Drosophila melanogaster and Neurospora crassa. GCN2 is the unique eIF2alpha kinase present in all eukaryotes from yeast to mammals (1). GCN2, a sensor of amino acid deficiency, plays a key role in yeast and mammals in modulating amino acid metabolism as part of adaptation to nutrient deprivation. (2). Results demonstrate that PERK and GCN2 function to cooperatively regulate eIF2alpha phosphorylation and cyclin D1 translation after unfolded protein response pathway activation (3).|
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A.Western blot analysis on HeLa cell lysates using anti-GCN2 phospho (pT899) RabMAb, 1:2000 dilution. Cells were either (A) untreated (B) treated with calyculin A