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Anti-GAP43 Antibody EP928Y
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for GAP43 (NM_001130064)
|A synthetic peptide corresponding to residues surrounding serine 41 of human GAP43 was used as an immunogen. This antibody detects both phosphorylated and nonphosphorylated GAP43.|
|Human, Mouse, Rat
||WB: 1:1000; IP: 1:40;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens growth associated protein 43 (GAP43), transcript variant 1|
|Growth associated protein GAP43 (B-50, F1, neuromodulin) is a phosphoprotein of the presynaptic membrane involved in synaptic reorganization and neural development. Phospholyated at Ser41 by protein kinase C (PKC), phospholyated GAP43 has been correlated to release of neurotransmitters in mature nervous system (1). Also, GAP43 plays an essential role in the maintenance mechanism of long-term potentiation (LTP) (2). These suggest GAP43 to play a role in synaptic plasticity. For neurons in development or regeneration, GAP43 is a major component of the growth cone, which enables elongation and navigation of developing axons (3). During periods of low activity in neurons, Calmodulin binds to GAP43 when Ca2+ is low, suggesting Calmodulin as a negative regulator of GAP43 (4).|
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A. Western blot analysis on human brain lysate using anti-GAP43 RabMAb.