G6PD is also known as glucose-6-phosphate dehydrogenase. It is a cytosolic enzyme whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its diversity. Many variants of G6PD, mostly produced from mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia (1).
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