Frizzled-6 represents a member of the 'frizzled' family, which are 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-6 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. It functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis (1).
Wnt Signaling Pathway
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