Anti-FZD6 Antibody, EPR7279

Also for FZD6 (NM_001164615)

Gene Name	Homo sapiens frizzled family receptor 6 (FZD6), transcript variant 2
Synonyms:	FZ-6; FZ6; HFZ6; NDNC10
Immunogen	A synthetic peptide corresponding to residues in human Frizzled-6 was used as an immunogen.
Buffer	Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Clone Name	EPR7279	Isotype
Species Reactivity	Human, Mouse, Rat	Concentration
Purification	(Protein A or G Sepharose)
Guaranteed Application *	WB	Suggested Dilutions	WB: 1:1,000 - 10,000;
Background	Frizzled-6 represents a member of the 'frizzled' family, which are 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. Frizzled-6 contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. It functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis (1).
Related Pathway	Melanogenesis Wnt Signaling Pathway

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WB Image

Western blot analysis on (A) HeLa, (B) HT-29, (C) 293T, and (D) Jurkat cell lysates using anti-Frizzled-6 RabMAb.

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Anti-FZD6 Antibody EPR7279

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