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Anti-FOXO4 Antibody EPR2150(3)
Also for FOXO4 (NM_001170931)
|A synthetic peptide corresponding to residues in human FOXO4 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, ASSAY, IHC
||WB: 1:10000 - 1:50000; IHC-P: 1:100 - 1:250
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 49% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for IP.
|Homo sapiens forkhead box O4 (FOXO4), transcript variant 2|
|AFX; AFX1; MLLT7|
Entrez Gene 4303 Human
|FOXO4 is a member of the O class of winged helix/forkhead transcription factor family. It is regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this protein on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia (1). A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity (2).|
|Transcription Factors |
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Western blot - Anti-FOXO4 antibody [EPR2150(3)]; All lanes : Anti-FOXO4 antibody [EPR2150(3)] at 1/10000 dilution.Lane 1 : HA-FOXO4 transfected 293T cell lysate.Lane 2 : HA-FOXO4.A3 (T32, S197 and S262 mutated to A) transfected 293T cell lysate.Lane 3 : 293T cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP-conjugated goat anti-rabbit at 1/2000 dilution.Predicted band size : 53 kDa.
Other-Anti-FOXO4 antibody [EPR2150(3)](TA310501); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXO4 antibody [EPR2150(3)]; TA310501, at 1/100 dilution, staining FOXO4 in paraffin-embedded Human placenta tissue by Immunohistochemistry.