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Home Antibody All anti-FMO3 antibodies

Anti-FMO3 Antibody EPR6968


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310492 Rabbit Monoclonal antibody against FMO3 100ul $325 In Stock
LC424145 FMO3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for FMO3 (NM_001002294)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human FMO3 was used as an immunogen.
Clone NameEPR6968 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:500 - 1:1000
Predicted MW Explanation 60 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens flavin containing monooxygenase 3 (FMO3), transcript variant 2
Alternative NamedJ127D3.1; FMOII; TMAU
Database LinkNP_001002294
Entrez Gene 2328 Human
Entrez Gene 14262 Mouse
Entrez Gene 84493 Rat
FunctionFlavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO family is composed of 5 proteins. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of FMO3, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Mutations in FMO3 cause the disorder trimethylaminuria (TMAu), which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non-odorous trimethylamine N-oxide (1).
Related PathwayTransmembraneDruggable Genome Drug metabolism - cytochrome P450

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-FMO3 antibody [EPR6968]; All lanes : Anti-FMO3 antibody [EPR6968] at 1/1000 dilution.Lane 1 : Human fetal liver lysate.Lane 2 : Human fetal kidney lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 60 kDa.
Other-Anti-FMO3 antibody [EPR6968](TA310492); Equilibrium disassociation constant (KD)..
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FMO3 antibody [EPR6968]; TA310492, at 1/500, staining FMO3 in Paraffin-embedded Human liver tissue by Immunohistochemistry.


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