FLAP, along with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites that have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. It localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation (1).
* Shipping is in business days
* OriGene provides validated application data and protocol, with money back guarantee.