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Home Antibody All anti-FGFR3 antibodies

Anti-FGFR3 Antibody EPR2304(3)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310487
  • Rabbit Monoclonal antibody against FGF Receptor 3 (FGFR3)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424902) , 20ug
100ul 325 3-7 Days
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WB(1)
FC(1)
Assay(1)
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Also for FGFR3 (NM_000142)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human FGF Receptor 3 was used as an immunogen.
Clone NameEPR2304(3) IsotypeIgG
Species ReactivityHuman, Mouse, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1
Alternative NameACH; CD333; CEK2; HSFGFR3EX; JTK4
Database LinkNP_000133
FunctionFGF Receptor 3 is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGF Receptor 3 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in FGF Receptor 3 lead to craniosynostosis and multiple types of skeletal dysplasia (1).
Related Pathway
MAPK signaling pathway

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WB Image
Western blot - Anti-FGFR3 antibody [EPR2304(3)]; All lanes : Anti-FGFR3 antibody [EPR2304(3)] at 1/1000 dilution.Lane 1 : Fetal brain lysate.Lane 2 : Fetal kidney lysate.Lane 3 : K562 lysate.Lane 4 : A549 lysate.Lane 5 : HepG2 lysate.Lane 6 : HeLa lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 88 kDa.
Assay Image
Other-Anti-FGFR3 antibody [EPR2304(3)](TA310487); Equilibrium disassociation constant (KD)..
FC Image
Flow Cytometry - Anti-FGFR3 antibody [EPR2304(3)]; Flow cytometry analysis of K562 cells labelling FGFR3 with TA310487 at 1/10 dilution (red). Rabbit IgG (negative) shown in green.

 

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