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Anti-FAS Antibody EPR5700
|A recombinant protein fragment corresponding to residues in human CD95 / Fas was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IHC-P: 1:250 - 1:500; ICC/IF: 1:250 - 1:500; FC: 1:10 - 1:100
|Does not react with Mouse, Rat. Is unsuitable for IP.|
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for IP.
|Homo sapiens Fas cell surface death receptor (FAS), transcript variant 1|
|ALPS1A; APO-1; APT1; CD95; FAS1; FASTM; TNFRSF6|
|CD95 / Fas is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and it has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of CD95 / Fas with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and it is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells (1).|
Cytokine-cytokine receptor interaction
MAPK signaling pathway
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Western blot - Anti-CD95 antibody [EPR5700 ]; All lanes : Anti-CD95 antibody [EPR5700 ] at 1/1000 dilution.Lane 1 : Ramos cell lysate.Lane 2 : HT-1080 cell lysate.Lane 3 : Raji cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 37 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD95 antibody [EPR5700 ]; Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelling CD95 with ab133619 antibody at a dilution of 1/250.