FAAH belongs to the amidase signature (AS) superfamily of serine hydrolases (1). It is responsible for the hydrolysis of a number of primary and secondary fatty acid amides, including the neuromodulatory compounds anandamide and oleamide (2). The most prominent substrates of FAAH are endocannabinoids, fatty acid amides that activate cannabinoid (CB) receptors. Through hydrolysis of endocannabinoids, FAAH terminates CB receptor signaling and controls the endocannabinoid tone (3).
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