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Anti-F2 Antibody EPR5188
|A synthetic peptide corresponding to residues in human Prothrombin was used as an immunogen.|
||Tissue culture supernatant
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt,ICC or IHC-P.
|Homo sapiens coagulation factor II (thrombin) (F2)|
|PT; RPRGL2; THPH1|
Entrez Gene 2147 Human
|Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade, which ultimately results in the stemming of blood loss. Prothrombin (F2) plays a role in maintaining vascular integrity during development and postnatal life (1). It converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Prothrombin also functions in blood homeostasis, inflammation, and wound healing (2). Mutations in this protein lead to various forms of thrombosis and dysprothrombinemia (1).|
|Secreted ProteinProteaseDruggable Genome Neuroactive ligand-receptor interactionComplement and coagulation cascadesRegulation of actin cytoskeleton|
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Western blot - Prothrombin antibody [EPR5188]; All lanes : Anti-Prothrombin antibody [EPR5188] at 1/1000 dilution.Lane 1 : Human serum lysate.Lane 2 : Human plasma lysate.Lane 3 : Human platelet lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 70 kDa.