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Home Antibody All anti-EXOSC7 antibodies

Anti-EXOSC7 Antibody EPR7452

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310471
  • Rabbit Monoclonal antibody against EXOSC7
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402399) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
IHC(1)
Assay(1)
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Also for EXOSC7 (NM_015004)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human EXOSC7 was used as an immunogen.
Clone NameEPR7452 IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, IHC Suggested DilutionsWB: 1:10000 - 1:50000; IP: 1:10 - 1:100; IHC-P: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt or ICC.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt or ICC.

Reference Data

Target NameHomo sapiens exosome component 7 (EXOSC7), transcript variant 1
Alternative NameEAP1; hRrp42p; p8; RRP42; Rrp42p
Database LinkNP_055819
Entrez Gene 23016 Human
FunctionEXOSC7 is a non-catalytic component of the RNA exosome complex, which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome is reported to be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs (1).
Related PathwayStem cell - Pluripotency RNA degradation

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-EXOSC7 antibody [EPR7452]; All lanes : Anti-EXOSC7 antibody [EPR7452] at 1/10000 dilution.Lane 1 : K562 cell lysate.Lane 2 : Jurkat cell lysate.Lane 3 : NCI-H460 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 32 kDa.
Assay Image
Other-Anti-EXOSC7 antibody [EPR7452](TA310471); Equilibrium disassociation constant (KD)..
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EXOSC7 antibody [EPR7452]; TA310471, at 1/100 dilution, staining EXOSC7 in paraffin-embedded Human colon tissue by Immunohistochemistry.

 

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