Endothelin B receptor is a G protein-coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in endothelin receptor type B (1).
Signaling by GPCR
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