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Home Antibody All anti-DSP antibodies

Anti-DSP Antibody EPR4383(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310428
  • Rabbit Monoclonal antibody against Desmoplakin (DSP)
100ul 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human Desmoplakin was used as an immunogen.
Clone NameEPR4383(2) IsotypeIgG
Species ReactivityHuman, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:1000 - 1:10000; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens desmoplakin (DSP), transcript variant 2
Alternative NameDP; DPI; DPII
Database LinkNP_001008844
FunctionDesmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus (1).
Related Pathway

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WB Image
Western blot - Desmoplakin antibody [EPR4383(2)]; All lanes : Anti-Desmoplakin antibody [EPR4383(2)] at 1/1000 dilution.Lane 1 : A431 cell lysate.Lane 2 : HACAT cell lysate.Lane 3 : BXPC-3 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 332 kDa.
IF Image
Immunocytochemistry/ Immunofluorescence - Desmoplakin antibody [EPR4383(2)]; Immunofluorescent staining of Desmoplakin in A431 cells using TA310428 at 1/100 dilution.

 

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