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 Home All anti-CYBB antibodies

Anti-CYBB Antibody EPR6991

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SKU Description Amount Price Availability*  
TA310385
  • Rabbit Monoclonal antibody against gp91-phox (CYBB)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC400139) , 20ug
 100ul $325 3-7 Days
TA802519S
  • Purified GAPDH mouse monoclonal antibody (Loading control), clone 2D9
 30ul
$100
$50*		 In Stock
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* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
WB(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human gp91-phox was used as an immunogen.
Clone NameEPR6991 Isotype
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000 - 10,000;
BufferStore at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.

Reference Data

Target NameHomo sapiens cytochrome b-245, beta polypeptide (CYBB)
Alternative NameAMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; NOX2; p91-PHOX
Database LinkNP_000388
Functiongp91-phox, or Cytochrome b (-245), is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole (1).
Related Pathway

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WB Image
Western blot analysis on (A) MCF-7, (B) HepG2, and (C) Caco-2 cell lysates using anti-gp91-phox RabMAb.

 

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