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Home Antibody All anti-CYBB antibodies

Anti-CYBB Antibody EPR6991


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA310385 Rabbit Monoclonal antibody against gp91-phox (CYBB) 100ul $325 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human gp91-phox was used as an immunogen.
Clone NameEPR6991 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, Assay Suggested DilutionsWB 1:5000
Predicted MW Explanation 65 kDa
BufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt,ICC/IF or IHC-P.

Reference Data

Target NameHomo sapiens cytochrome b-245, beta polypeptide (CYBB)
Alternative NameAMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
Database LinkNP_000388
Entrez Gene 1536 Human
Entrez Gene 13058 Mouse
Entrez Gene 66021 Rat
Functiongp91-phox, or Cytochrome b (-245), is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole (1).
Related PathwayIon Channels: OtherTransmembraneDruggable Genome Leukocyte transendothelial migration

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-NOX2/gp91phox antibody [EPR6991]; All lanes : Anti-NOX2/gp91phox antibody [EPR6991] at 1/1000 dilution.Lane 1 : MCF-7 cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Caco-2 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 65 kDa.Observed band size : 60 kDa .

Assay Image
Other-Anti-NOX2/gp91phox antibody [EPR6991](TA310385); Equilibrium disassociation constant (KD)..


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