Home Antibody All anti-CYBB antibodies
Anti-CYBB Antibody EPR6991
Also for CYBB (NM_000397)
|A synthetic peptide corresponding to residues in human gp91-phox was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
|Homo sapiens cytochrome b-245, beta polypeptide (CYBB)|
|AMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX|
Entrez Gene 1536 Human
Entrez Gene 13058 Mouse
Entrez Gene 66021 Rat
|gp91-phox, or Cytochrome b (-245), is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole (1). |
|Ion Channels: OtherTransmembraneDruggable Genome Leukocyte transendothelial migration|
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Western blot - Anti-NOX2/gp91phox antibody [EPR6991]; All lanes : Anti-NOX2/gp91phox antibody [EPR6991] at 1/1000 dilution.Lane 1 : MCF-7 cell lysate.Lane 2 : HepG2 cell lysate.Lane 3 : Caco-2 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 65 kDa.Observed band size : 60 kDa .
Other-Anti-NOX2/gp91phox antibody [EPR6991](TA310385); Equilibrium disassociation constant (KD)..