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Anti-CTCF Antibody EPR7313
Also for CTCF (NM_001191022)
|A synthetic peptide corresponding to residues in human CTCF was used as an immunogen.|
|Human, Mouse, Rat
||Lot dependent; please refer to CoA along with shipment
Preservative: 0.01% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.05% BSA
|Tissue culture supernatant
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens CCCTC-binding factor (zinc finger protein) (CTCF), transcript variant 2|
|CTCF is a member of the BORIS + CTCF family and is a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in CTCF have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors (1).|
TGF Beta Signaling Pathway
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Western blot - Anti-CTCF antibody [EPR7313]; All lanes : Anti-CTCF antibody [EPR7313] at 1/1000 dilution.Lane 1 : U937 cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : MDA-MB-435 cell lysate.Lane 4 : 293T cell lysate.Lane 5 : Caco-2 cell lysate.Lane 6 : RAW 264.7 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit at 1/2000 dilution.Predicted band size : 83 kDa.
Other-Anti-CTCF antibody [EPR7313](TA310367); Equilibrium disassociation constant (KD)..