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Anti-COMT Antibody EPR6491(B)


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against COMT
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400254) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human COMT was used as an immunogen.
Clone NameEPR6491(B) IsotypeIgG
Species ReactivityRat, Human (Does not react with: Mouse) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, ASSAY, FC Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:10 - 1:100
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens catechol-O-methyltransferase (COMT), transcript variant 1
Alternative NameHEL-S-98n
Database LinkNP_000745
Entrez Gene 1312 Human
Entrez Gene 24267 Rat
FunctionCatechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson's disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini (1).
Related PathwayTransmembraneDruggable Genome Tyrosine metabolismMetabolic pathways

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Anti-COMT antibody [EPR6491(B)]; All lanes : Anti-COMT antibody [EPR6491(B)] at 1/1000 dilution.Lane 1 : Fetal Liver lysate .Lane 2 : A431 cell lysate .Lane 3 : MOLT4 cell lysate.Lysates/proteins at 10 ug per lane.developed using the ECL technique.Predicted band size : 30 kDa.
Other-Anti-COMT antibody [EPR6491(B)](TA310342); Equilibrium disassociation constant (KD)..
Flow Cytometry - Anti-COMT antibody [EPR6491(B)]; TA310342, at 1/10 dilution staining COMT in A431 cells, (Red) compared to a nonspecific negative control antibody (Green) by Flow Cytometry.


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