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Home Antibody All anti-Cdc37 antibodies

Anti-Cdc37 PHOSPHO Antibody EPR4879

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310303
  • Rabbit Monoclonal antibody against Cdc37, pS13 (Phospho-specific)
100ul 325 3-7 Days
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WB(1)
IHC(1)
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Also for Cdc37 (NM_007065)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding Serine 13 of human Cdc37 was used as an immunogen. This antibody only detects Cdc37 phosphorylated at Serine 13.
Clone NameEPR4879 IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IP: 1:10 - 1:100; IHC-P: 1:50 - 1:100; ICC: 1:250 - 1:500
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens cell division cycle 37 (CDC37)
Alternative NameP50CDC37
Database LinkNP_008996
FunctionCdc37 is a cell division cycle control protein of Saccharomyces cerevisiae. It is a molecular chaperone with specific function in cell signal transduction. It has been shown to form a complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. Cdc37 is thought to play a critical role in directing Hsp90 to its target kinases (1). Phosphorylation of serine 13 is required for the biochemical function of Cdc37, namely for its kinase binding activity and its ability to stimulate the nucleotide-modulated conformational switching of Hsp90 (2).
Related Pathway

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WB Image
Western blot - Cdc37 (phospho S13) antibody [EPR4879]; All lanes : Anti-Cdc37 (phospho S13) antibody [EPR4879].Lane 1 : Jurkat cell lysate (untreated).Lane 2 : Jurkat cell lysate (treated with Alkaline Phosphatase).Lysates/proteins at 10 µg per lane.Predicted band size : 44 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cdc37 (phospho S13) antibody [EPR4879]; TA310303, at 1/50, staining Cdc37 in paraffin-embedded human transitional cell carcinoma tissue by Immunohistochemistry.

 

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