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Anti-CD59 Antibody EPR6425(2)
Also for CD59 (NM_000611)
|A synthetic peptide corresponding to residues in the extracellular domain of human CD59 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
|pH: 7.20; Preservative: 0.01% Sodium azide; Constituents: 48% PBS, 50% Glycerol, 0.05% BSA|
|Is unsuitable for Flow Cyt,ICC or IP.
|Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 2|
|16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;|
Entrez Gene 966 Human
|CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this protein cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction (1). |
|Druggable Genome Complement and coagulation cascadesHematopoietic cell lineage|
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Western blot - Anti-CD59 antibody [EPR6425(2)]; All lanes : Anti-CD59 antibody [EPR6425(2)] at 1/1000 dilution.Lane 1 : HUVEC cell lysate.Lane 2 : BxPC 3 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 14 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD59 antibody [EPR6425(2)]; Immunohistochemical analysis of CD59 in paraffin embedded Human placenta tissue labelled with TA310287 at a 1/100 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD59 antibody [EPR6425(2)]; Immunohistochemical analysis of CD59 in paraffin embedded Human tonsil tissue labelled with TA310287 at a 1/100 dilution.