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Home Antibody All anti-CD59 antibodies

Anti-CD59 Antibody EPR6425(2)

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310287
  • Rabbit Monoclonal antibody against CD59
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424608) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(2)
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Also for CD59 (NM_000611)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the extracellular domain of human CD59 was used as an immunogen.
Clone NameEPR6425(2) IsotypeTissue culture supernatant
Species ReactivityHuman ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: 1:100 - 1:250
BufferDoes not react with Mouse, Rat. Is unsuitable for Flow Cyt,ICC or IP.
Purification pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 48% PBS, 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC or IP.

Reference Data

Target NameHomo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 2
Alternative Name16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2;
Database LinkNP_000602
FunctionCD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 also plays a role in signal transduction pathways in the activation of T cells. Mutations in this protein cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction (1).
Related Pathway
Hematopoietic cell lineage

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WB Image
Western blot - Anti-CD59 antibody [EPR6425(2)]; All lanes : Anti-CD59 antibody [EPR6425(2)] at 1/1000 dilution.Lane 1 : HUVEC cell lysate.Lane 2 : BxPC 3 cell lysate.Lysates/proteins at 10 µg per lane.Secondary.Goat anti-rabbit HRP conjugated antibody at 1/2000 dilution.Predicted band size : 14 kDa.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD59 antibody [EPR6425(2)]; Immunohistochemical analysis of CD59 in paraffin embedded Human placenta tissue labelled with TA310287 at a 1/100 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD59 antibody [EPR6425(2)]; Immunohistochemical analysis of CD59 in paraffin embedded Human tonsil tissue labelled with TA310287 at a 1/100 dilution.

 

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