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Anti-CD45 Antibody EP350


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against CD45
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401003) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD45 was used as an immunogen.
Clone NameEP350 IsotypeIgG
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1
Alternative NameB220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Database LinkNP_002829
Entrez Gene 5788 Human
Entrez Gene 19264 Mouse
FunctionCD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in hematopoietic cells except erythrocytes and platelets (1). CD 45 has been implicated in activating, differentiating and the development of the immune system. It regulates T-or B-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. It is also required for T- and B-cell activation by regulating Lck & Fyn and Lyn & Blk, respectively (2). Additionally, the expression of CD45's 5 isoforms can be seen in various stages of differentiation of normal hematopoietic cells, depending on the activation status of the cell (3).
Related PathwayES Cell Differentiation/IPSTransmembranePhosphataseDruggable Genome Cell adhesion molecules (CAMs)T cell receptor signaling pathwayFc gamma R-mediated phagocytosisPrimary immunodeficiency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - CD45RO antibody [EP350]; All lanes : Anti-CD45RO antibody [EP350] at 1/1000 dilution.Lane 1 : Jurkat lysate.Lane 2 : MOLT4 lysate.Lane 3 : Human tonsil lysate.Lysates/proteins at 10 ug per lane.Predicted band size : 147 kDa.Observed band size : 180 kDa .


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