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Home Antibody All anti-CD45 antibodies

Anti-CD45 Antibody EP350

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA310279
  • Rabbit Monoclonal antibody against CD45
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401003) , 20ug
100ul $325 3-7 Days
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WB(1)
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Also for CD45 (NM_002838)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues in human CD45 was used as an immunogen.
Clone NameEP350 IsotypeTissue culture supernatant
Species ReactivityHuman, Mouse Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000
BufferDoes not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
Purification pH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for Flow Cyt,ICC,IHC-P or IP.

Reference Data

Target NameHomo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1
Alternative NameB220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200
Database LinkNP_002829
FunctionCD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in hematopoietic cells except erythrocytes and platelets (1). CD 45 has been implicated in activating, differentiating and the development of the immune system. It regulates T-or B-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. It is also required for T- and B-cell activation by regulating Lck & Fyn and Lyn & Blk, respectively (2). Additionally, the expression of CD45's 5 isoforms can be seen in various stages of differentiation of normal hematopoietic cells, depending on the activation status of the cell (3).
Related Pathway

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WB Image
Western blot - CD45RO antibody [EP350]; All lanes : Anti-CD45RO antibody [EP350] at 1/1000 dilution.Lane 1 : Jurkat lysate.Lane 2 : MOLT4 lysate.Lane 3 : Human tonsil lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 147 kDa.Observed band size : 180 kDa .

 

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