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Anti-CD45 Antibody EP350
Also for CD45 (NM_002838)
|A synthetic peptide corresponding to residues in human CD45 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|Does not react with Rat. Is unsuitable for Flow Cyt,ICC,IHC-P or IP.|
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens protein tyrosine phosphatase, receptor type, C (PTPRC), transcript variant 1|
|B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200|
|CD45, also known as the leukocyte common antigen (LCA), is a transmembrane protein-tyrosine phosphatase (PTPase) that is expressed in hematopoietic cells except erythrocytes and platelets (1). CD 45 has been implicated in activating, differentiating and the development of the immune system. It regulates T-or B-cell activation during receptor-specific recognition by dephosphorylating tyrosine residues in protein kinase substrates. It is also required for T- and B-cell activation by regulating Lck & Fyn and Lyn & Blk, respectively (2). Additionally, the expression of CD45's 5 isoforms can be seen in various stages of differentiation of normal hematopoietic cells, depending on the activation status of the cell (3).|
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Western blot - CD45RO antibody [EP350]; All lanes : Anti-CD45RO antibody [EP350] at 1/1000 dilution.Lane 1 : Jurkat lysate.Lane 2 : MOLT4 lysate.Lane 3 : Human tonsil lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 147 kDa.Observed band size : 180 kDa .