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Anti-CCNB1 Phospho Antibody EPR3670
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Also for CCNB1 (NM_031966)
|A phospho specific peptide corresponding to residues surrounding Serine 126 of human Cyclin B1 was used as an immunogen. This antibody only detects Cyclin B1 phosphorylated at Serine 126.|
||WB: 1:1,000 - 10,000; ICC: 1:50 - 100; IP: 1:20; FC: 1:50;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens cyclin B1 (CCNB1)|
|Cyclin B1 regulates mitosis in conjunction with Cdc2 kinase to form the Cdc2-cyclin B1 complex also known as maturation promoting factor (MPF) (1-2). The activation of the complex begins when the regulatory subunit, cyclin B1, associates with the catalytic subunit of Cdc2. Cyclin B1 levels rise during S phase and G2, and peak at mitosis. The timing of mitosis can also be influenced by changes in cyclin B1Cdc2 localization. Cyclin B1 is mostly located in the cytoplasm during S and G2 phases and then rapidly accumulates in the nucleus at the onset of prophase (3).|
Hedgehog signaling pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-Cyclin B1 (pS126) RabMAb. Cells were either (A) untreated or (B) treated with Nocodazole.