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[anti-HA]
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[Akt3]
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[LA]
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[JAK2]
Homo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
Synonyms:
C-CBL; CBL2; FRA11B; NSLL; RNF55
Immunogen
A phospho specific peptide corresponding to residues surrounding tyrosine 700 were used as an immunogen. This antibody detects Cbl phosphorylated on tyrosine 700.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4). It has been demonstrated that tyrosines 700, 731, and 774 are the major tyrosine phosphorylation sites of c-Cbl in T cells in response to pervanadate treatment, as well as in response to TcR/CD3 ligation (5).
Related Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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A. Western blot analysis on Jurkat cell lysate using anti-Phospho-Cbl (pY700) RabMAb, 1:10,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
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