Homo sapiens Cbl proto-oncogene, E3 ubiquitin protein ligase (CBL)
Synonyms:
C-CBL; CBL2; FRA11B; NSLL; RNF55
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr731 of human Cbl was used as immunogen. The antibody detects Cbl phosphorylated on Tyrosine 731.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
c-Cbl, product of c-cbl proto-oncogene, is a 120 kDa cytoplasmic protein involved in tyrosine kinase-dependent signaling pathways (1-3). c-Cbl is one of the earliest targets of tyrosine phosphorylation in response to a number of cellular stimuli. For instance, stimulation of growth factor receptors by EGF, PDGF, NGF and FGF, results in c-Cbl tyrosine phosphorylation, in lymphoid and other cell lines (4).
Related Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
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A. Western blot analysis on Raji cell lysates using anti-Phospho-c-Cbl (pY731) RabMAb, 1:2000 dilution. Cells were either (A) untreated (B) treated with pervanadate
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