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Anti-CAV2 Phospho Antibody EP2221Y
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Also for CAV2 (NM_001206747)
|A phospho specific peptide corresponding to residues surrounding tyrosine 27 of human Caveolin2. This antibody detects Caveloin2 phosphorylated at tyrosine 27.|
||WB: 1:1,000 - 10,000; IHC 1:100 - 250; ICC: 1:50;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens caveolin 2 (CAV2), transcript variant 1|
|Caveolae are cholesterol/sphingolipid-rich microdomains of the plasma membrane that have been implicated in signal transduction and vesicular trafficking. Caveolins are a family of caveolae-associated integral membrane proteins (1). Caveolin, a 21- to 24-kDa integral membrane protein, is a principal component of caveolae membranes. Caveolin interacts directly with heterotrimeric guanine nucleotide binding proteins (G proteins) and can functionally regulate their activity. Caveolins 1 and 2 are similar in most respects, however, caveolin-1 and caveolin-2 differ in their functional interactions with heterotrimeric G proteins, possibly explaining why caveolin-1 and -2 are coexpressed within a single cell (2). Caveolin-2 is up-regulated in response to the mechanical injury of differentiated PC12 cells; up-regulation of caveolin-2 under these conditions is strictly dependent on continued treatment with NGF. Robust expression of caveolin-1 and -2 is also observed along the entire cell surface of DRG neurons, including high levels on growth cones. These findings demonstrate that neuronal cells express caveolins (1).|
EGFR1 Signaling Pathway
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A. Western blot analysis on HeLa cell lysates using anti-Phospho-Caveolin2 (pY27) RabMAb, 1:2000 dilution. Cells were either (A) untreated (B) treated with pervanadate.