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Anti-ATG3 Antibody EPR4802
* Buy one primary antibody, get 50% off a GAPDH loading control antibody.
Also for ATG3 (NM_022488)
|A synthetic peptide corresponding to residues on the C-terminus in human Atg3 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1:10,000 - 50,000;
|Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.|
|Homo sapiens autophagy related 3 (ATG3)|
|APG3; APG3-LIKE; APG3L; PC3-96|
|Autophagy is a process of bulk degradation of cytoplasmic components by the lysosome or vacuole (1). Atg3 is an E2-like enzyme involved in autophagy and mitochondrial homeostasis. It catalyzes the conjugation of Atg8-like proteins to phosphatidylethanolamine (PE), which is essential to autophagy. Atg3 also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of Atg12 to itself; Atg12 conjugation to Atg3 plays a role in mitochondrial homeostasis but not in autophagy. Atg7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with Atg3 (2).|
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Western blot analysis on (A) K562, (B) HeLa, and (C) Jurkat cell lysates using anti-Atg3 RabMAb.
Flow cytometric analysis of permeabilized Jurkat cells using anti-Atg3 RabMAb (red) or a rabbit IgG (negative) (green).