Home Antibody All anti-ATP2B1 antibodies
Also for ATP2B1 (NM_001682)
|Peptide with sequence C-KQDGAIENRNKAKAQD, from the internal region of the protein sequence according to NP_001001323.1; NP_001673.2.|
|Test: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Pig, Cow
||Lot dependent; please refer to CoA along with shipment
|Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.|
|Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
|Homo sapiens ATPase, Ca++ transporting, plasma membrane 1 (ATP2B1), transcript variant 2|
Entrez Gene 490 Human
Entrez Gene 67972 Mouse
Entrez Gene 29598 Rat
Entrez Gene 403480 Dog
|The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. |
|TransmembraneDruggable Genome Calcium signaling pathway|
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TA309535 (0.03µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.