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Home Antibody All anti-TLR4 antibodies

Anti-TLR4 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA309486 Rabbit Polyclonal anti-TLR4 Antibody 100ug $325 In Stock
LC408575 TLR4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenDeveloped against a synthetic peptide corresponding to amino acids 420-435 of human TLR4.
Clone Name Isotype
Species ReactivityHuman, Mouse ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsFC, IHC, ICC, WB
BufferPBS pH7.4, 50% glycerol

Reference Data

Target NameHomo sapiens toll-like receptor 4 (TLR4), transcript variant 3
Alternative NameARMD10; CD284; TLR-4; TOLL
Database LinkNP_003257
Entrez Gene 7099 Human
Entrez Gene 21898 Mouse
FunctionThe protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq].
Related PathwayTransmembraneDruggable Genome Toll-like receptor signaling pathwayPathogenic Escherichia coli infection

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of TLR4 using a 1:1000 dilution of TA309486.

IHC Image
IHC analysis of TLR4 using TA309486, tested in formalin-fixed paraffin-embedded mouse spleen tissue.


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