This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway
MAPK signaling pathway
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Western blot analysis of P90 RSK1 immuno-precipitated from the mouse brain extract (right) and using RSK1-HRP as a probe. Immuno-precipitated negative control (left).
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