Home Antibody All anti-DUX4 antibodies
Anti-DUX4 Antibody P2B1
Also for DUX4 (NM_033178)
|C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag|
||Lot dependent; please refer to CoA along with shipment
||WB, IF, IHC
|TBS pH7.4, 50% glycerol|
|Homo sapiens double homeobox 4 (DUX4)|
Entrez Gene 22947 Human
|This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq]. |
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Western blot using anti-DUX4 N-terminus mouse monoclonal on C2C12 cells transfected with pCS2+DUX4, which contains an additional upstream start site.
Immmunofluorescence staining using mouse monoclonal anti-DUX4 N-terminus on C2C12 myoblasts transfected with pCS2+DUX4. Counter-stained with DAPI for nuclei.