Home Antibody All anti-CACNB4 antibodies
Anti-CACNB4 Antibody S10-7
Also for CACNB4 (NM_000726)
|Synthetic peptide amino acids 458-474 of rat CavB4|
|Human, Mouse, Rat
||WB, IP, IHC
|PBS pH7.4, 50% glycerol|
|Homo sapiens calcium channel, voltage-dependent, beta 4 subunit (CACNB4), transcript variant 2|
|CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6|
|This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
MAPK signaling pathway
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Western blot analysis of CavBeta4 in T-CHO lysates using a 1:1000 dilution of SMC-318.