Home Antibody All anti-CNTNAP2 antibodies
Anti-CNTNAP2 Antibody S67-25
Also for CNTNAP2 (NM_014141)
|Fusion protein 96-1265 (extracellular domain) ofhuman CASPR2|
|Human, Mouse, Rat
||WB, IHC, IP
|PBS pH7.4, 50% glycerol|
|Homo sapiens contactin associated protein-like 2 (CNTNAP2)|
|AUTS15; CASPR2; CDFE; NRXN4; PTHSL1|
|This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation. |
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IHC analysis of CASPR2 in frozen sections of mouse brain extract using SMC-372.