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Home Antibody All anti-CNTNAP2 antibodies

Anti-CNTNAP2 Antibody S67-25

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA309305
  • Mouse Monoclonal anti-CNTNAP2 Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402278) , 20ug
100ug $325 3-7 Days
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IHC(1)
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Also for CNTNAP2 (NM_014141)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein 96-1265 (extracellular domain) ofhuman CASPR2
Clone NameS67-25 IsotypeIgG2A
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *IHC Suggested DilutionsWB, IHC, IP
BufferPBS pH7.4, 50% glycerol

Reference Data

Target NameHomo sapiens contactin associated protein-like 2 (CNTNAP2)
Alternative NameAUTS15; CASPR2; CDFE; NRXN4; PTHSL1
Database LinkNP_054860
FunctionThis gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.
Related Pathway

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IHC Image
IHC analysis of CASPR2 in frozen sections of mouse brain extract using SMC-372.

 

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