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Anti-MECP2 PHOSPHO Antibody
Also for MECP2 (NM_004992)
|Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser80 conjugated to KLH|
|human, mouse, rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1,000, IHC 1:100
|100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
|Homo sapiens methyl CpG binding protein 2 (Rett syndrome) (MECP2), transcript variant 1|
|AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT|
|DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq]. |
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Western blot of neonatal rat brain showing specific immunolabeling of the ~ 75k MeCP2 protein phosphorylated at Ser80.