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Home Antibody All anti-MECP2 antibodies

Anti-MECP2 PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA309165
  • Rabbit Anti-MeCP2 (Ser80) Antibody (Phospho-Specific)
100ul 325 In Stock
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WB(1)

OriGene Data

ImmunogenSynthetic phospho-peptide corresponding to amino acid residues surrounding Ser80 conjugated to KLH
Clone Name IsotypeIgG
Species Reactivityhuman, mouse, rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1,000, IHC 1:100
Buffer100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification Serum

Reference Data

Target NameHomo sapiens methyl CpG binding protein 2 (MECP2), transcript variant 1
Alternative NameAUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX; RS; RTS; RTT
Database LinkNP_004983
Entrez Gene 4204 Human
Entrez Gene 17257 Mouse
Entrez Gene 29386 Rat
FunctionDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq].
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot of neonatal rat brain showing specific immunolabeling of the ~ 75k MeCP2 protein phosphorylated at Ser80.

 

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