Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq].
Related Pathway
EGFR1 Signaling Pathway
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Mixed neuron-glial cultures stained with alpha-synuclein (red) and
chicken MAP2 (cat.# 1100-MAP2) (green). The alpha-synuclein antibody stains vesicular
structures, the perikarya and processes of the neurons in this image.
Mixed neuron-glial cultures stained with alpha-synuclein (red) and
chicken MAP2 (cat.# 1100-MAP2) (green). The alpha-synuclein antibody stains vesicular
structures, the perikarya and processes of the neurons in this image.
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